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CRL4(VprBP) E3 ligase promotes monoubiquitylation and chromatin binding of TET dioxygenases
DNA methylation at the C-5 position of cytosine (5mC) regulates gene expression and plays pivotal roles in various biological processes. The TET dioxygenases iterative oxidation of 5mC, leading to eventual demethylation intermediate. Inactivation of TET enzymes causes multi-stage developmental defec...
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| Pubblicato in: | Mol Cell |
|---|---|
| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4304937/ https://ncbi.nlm.nih.gov/pubmed/25557551 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.12.002 |
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