Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR

CD4(+) T regulatory (T(reg)) cells are central to immune homeostasis, their phenotypic heterogeneity reflecting the diverse environments and target cells they regulate. To understand this heterogeneity, we combined single-cell RNAseq, activation reporter and TCR analysis to profile thousands of T(re...

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Bibliographic Details
Published in:Nat Immunol
Main Authors: Zemmour, David, Zilionis, Rapolas, Kiner, Evgeny, Klein, Allon M, Mathis, Diane, Benoist, Christophe
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6069633/
https://ncbi.nlm.nih.gov/pubmed/29434354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-018-0051-0
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