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Increasing cardiac pyruvate dehydrogenase flux during chronic hypoxia improves acute hypoxic tolerance

KEY POINTS: The cardiac metabolic reprogramming seen in heart diseases such as myocardial infarction and hypertrophy shares similarities with that seen in chronic hypoxia, but understanding of how the hypoxic heart responds to further hypoxic challenge – hypoxic tolerance – is limited. The pyruvate...

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Podrobná bibliografie
Vydáno v:J Physiol
Hlavní autoři: Handzlik, Michal K., Constantin‐Teodosiu, Dumitru, Greenhaff, Paul L., Cole, Mark A.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6068244/
https://ncbi.nlm.nih.gov/pubmed/29383727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP275357
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