CXCR3(+) T Follicular Helper Cells Induced by Co-Administration of RTS,S/AS01B and Viral-Vectored Vaccines Are Associated With Reduced Immunogenicity and Efficacy Against Malaria

A malaria vaccine strategy targeting multiple lifecycle stages may be required to achieve a high level of efficacy. In two Phase IIa clinical trials, we tested immunogenicity and efficacy of RTS,S/AS01B administered alone, in a staggered regimen with viral-vectored vaccines or co-administered with v...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Bowyer, Georgina, Grobbelaar, Amy, Rampling, Tommy, Venkatraman, Navin, Morelle, Danielle, Ballou, Ripley W., Hill, Adrian V. S., Ewer, Katie J.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6068239/
https://ncbi.nlm.nih.gov/pubmed/30090099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01660
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