Topical ferumoxytol nanoparticles disrupt biofilms and prevent tooth decay in vivo via intrinsic catalytic activity

Ferumoxytol is a nanoparticle formulation approved by the U.S. Food and Drug Administration for systemic use to treat iron deficiency. Here, we show that, in addition, ferumoxytol disrupts intractable oral biofilms and prevents tooth decay (dental caries) via intrinsic peroxidase-like activity. Feru...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Liu, Yuan, Naha, Pratap C., Hwang, Geelsu, Kim, Dongyeop, Huang, Yue, Simon-Soro, Aurea, Jung, Hoi-In, Ren, Zhi, Li, Yong, Gubara, Sarah, Alawi, Faizan, Zero, Domenick, Hara, Anderson T., Cormode, David P., Koo, Hyun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6068184/
https://ncbi.nlm.nih.gov/pubmed/30065293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05342-x
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