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Systems analysis of intracellular pH vulnerabilities for cancer therapy
A reverse pH gradient is a hallmark of cancer metabolism, manifested by extracellular acidosis and intracellular alkalization. While consequences of extracellular acidosis are known, the roles of intracellular alkalization are incompletely understood. By reconstructing and integrating enzymatic pH-d...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6068141/ https://ncbi.nlm.nih.gov/pubmed/30065243 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05261-x |
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