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Systems analysis of intracellular pH vulnerabilities for cancer therapy
A reverse pH gradient is a hallmark of cancer metabolism, manifested by extracellular acidosis and intracellular alkalization. While consequences of extracellular acidosis are known, the roles of intracellular alkalization are incompletely understood. By reconstructing and integrating enzymatic pH-d...
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| Udgivet i: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6068141/ https://ncbi.nlm.nih.gov/pubmed/30065243 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05261-x |
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