Acid-induced downregulation of ASS1 contributes to the maintenance of intracellular pH in cancer

Downregulation of the urea cycle enzyme argininosuccinate synthase (ASS1) by either promoter methylation or by HIF1α is associated with increased metastasis and poor prognosis in multiple cancers. We have previously shown that in normoxic conditions, ASS1 downregulation facilitates cancer cell proli...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Silberman, Alon, Goldman, Omer, Assayag, Odeya Boukobza, Jacob, Adi, Rabinovich, Shiran, Adler, Lital, Sang Lee, Joo, Keshet, Rom, Sarver, Alona, Frug, Julia, Stettner, Noa, Galai, Sivan, Persi, Erez, Bahar Halpern, Keren, Zaltsman-Amir, Yehudit, Pode-Shakked, Ben, Eilam, Raya, Anikster, Yair, Nagamani, Sandesh CS, Ulitsky, Igor, Ruppin, Eytan, Erez, Ayelet
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6359973/
https://ncbi.nlm.nih.gov/pubmed/30573518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-1062
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