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Toward Small-Molecule Inhibition of Protein–Protein Interactions: General Aspects and Recent Progress in Targeting Costimulatory and Coinhibitory (Immune Checkpoint) Interactions

Protein-protein interactions (PPIs) that are part of the costimulatory and coinhibitory (immune checkpoint) signaling are critical for adequate T cell response and are important therapeutic targets for immunomodulation. Biologics targeting them have already achieved considerable clinical success in...

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Detalhes bibliográficos
Publicado no:Curr Top Med Chem
Main Authors: Bojadzic, Damir, Buchwald, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6067980/
https://ncbi.nlm.nih.gov/pubmed/29848279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1568026618666180531092503
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