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Double-barreled gun: Combination of PARP inhibitor with conventional chemotherapy
DNA repair pathways are evolutionarily conserved molecular mechanisms that maintain the integrity of genomic DNA. In cancer therapies, the integrity and activity of DNA repair pathways predict therapy resistance and disease outcome. Members of the poly (ADP-ribose) polymerase (PARP) family initiate...
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| Pubblicato in: | Pharmacol Ther |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6067963/ https://ncbi.nlm.nih.gov/pubmed/29621593 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharmthera.2018.03.006 |
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