Investigations on the mode of action of gephyronic acid, an inhibitor of eukaryotic protein translation from myxobacteria

The identification of inhibitors of eukaryotic protein biosynthesis, which are targeting single translation factors, is highly demanded. Here we report on a small molecule inhibitor, gephyronic acid, isolated from the myxobacterium Archangium gephyra that inhibits growth of transformed mammalian cel...

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Sparad:
Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Muthukumar, Yazh, Münkemer, Johanna, Mathieu, Daniel, Richter, Christian, Schwalbe, Harald, Steinmetz, Heinrich, Kessler, Wolfgang, Reichelt, Joachim, Beutling, Ulrike, Frank, Ronald, Büssow, Konrad, van den Heuvel, Joop, Brönstrup, Mark, Taylor, Richard E., Laschat, Sabine, Sasse, Florenz
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2018
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6067752/
https://ncbi.nlm.nih.gov/pubmed/30063768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0201605
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