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In Vitro Hepatic Oxidative Biotransformation of Trimethoprim
Trimethoprim (TMP) has been widely used since the 1960s, both alone and in combination with sulfamethoxazole. Unfortunately, information regarding the role that cytochrome P450 enzymes (P450s) play in the formation of TMP primary metabolites is scarce. Hence, we undertook in vitro studies to identif...
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| Published in: | Drug Metab Dispos |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
The American Society for Pharmacology and Experimental Therapeutics
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6067384/ https://ncbi.nlm.nih.gov/pubmed/26138612 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.065193 |
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