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In Vitro Hepatic Oxidative Biotransformation of Trimethoprim
Trimethoprim (TMP) has been widely used since the 1960s, both alone and in combination with sulfamethoxazole. Unfortunately, information regarding the role that cytochrome P450 enzymes (P450s) play in the formation of TMP primary metabolites is scarce. Hence, we undertook in vitro studies to identif...
Guardat en:
| Publicat a: | Drug Metab Dispos |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The American Society for Pharmacology and Experimental Therapeutics
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6067384/ https://ncbi.nlm.nih.gov/pubmed/26138612 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.065193 |
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