The evolution of single cell-derived colorectal cancer cell lines is dominated by the continued selection of tumor-specific genomic imbalances, despite random chromosomal instability

Intratumor heterogeneity is a major challenge in cancer treatment. To decipher patterns of chromosomal heterogeneity, we analyzed six colorectal cancer cell lines by multiplex interphase FISH (miFISH). The mismatch-repair-deficient cell lines DLD-1 and HCT116 had the most stable copy numbers, wherea...

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Dades bibliogràfiques
Publicat a:Carcinogenesis
Autors principals: Wangsa, Darawalee, Braun, Rüdiger, Schiefer, Madison, Gertz, Edward Michael, Bronder, Daniel, Quintanilla, Isabel, Padilla-Nash, Hesed M, Torres, Irianna, Hunn, Cynthia, Warner, Lidia, Buishand, Floryne O, Hu, Yue, Hirsch, Daniela, Gaiser, Timo, Camps, Jordi, Schwartz, Russell, Schäffer, Alejandro A, Heselmeyer-Haddad, Kerstin, Ried, Thomas
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2018
Matèries:
Biology, Genetics and Epigenetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6067130/
https://ncbi.nlm.nih.gov/pubmed/29800151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgy068
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