Carbonyl reduction of NNK by recombinant human lung enzymes: identification of HSD17β12 as the reductase important in (R)-NNAL formation in human lung

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is the most abundant and carcinogenic tobacco-specific nitrosamine in tobacco and tobacco smoke. The major metabolic pathway for NNK is carbonyl reduction to form the (R) and (S) enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL)...

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Udgivet i:Carcinogenesis
Main Authors: Ashmore, Joseph H, Luo, Shaman, Watson, Christy J W, Lazarus, Philip
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
Fag:
Carcinogenesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6067128/
https://ncbi.nlm.nih.gov/pubmed/29788210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgy065
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