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Association between glucuronidation genotypes and urinary NNAL metabolic phenotypes in smokers
BACKGROUND: The most abundant and potent carcinogenic tobacco-specific nitrosamines in tobacco and tobacco smoke is 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). In vivo, NNK is rapidly metabolized to both the (R)- and (S)-enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL),...
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| Veröffentlicht in: | Cancer Epidemiol Biomarkers Prev |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5087993/ https://ncbi.nlm.nih.gov/pubmed/27197298 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-15-1245 |
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