Could Conservative Iron Chelation Lead to Neuroprotection in Amyotrophic Lateral Sclerosis?

Iron accumulation has been observed in mouse models and in both sporadic and familial forms of amyotrophic lateral sclerosis (ALS). Iron chelation could reduce iron accumulation and the related excess of oxidative stress in the motor pathways. However, classical iron chelation would induce systemic...

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Publicado en:Antioxid Redox Signal
Autores principales: Moreau, Caroline, Danel, Véronique, Devedjian, Jean Christophe, Grolez, Guillaume, Timmerman, Kelly, Laloux, Charlotte, Petrault, Maud, Gouel, Flore, Jonneaux, Aurélie, Dutheil, Mary, Lachaud, Cédrick, Lopes, Renaud, Kuchcinski, Grégory, Auger, Florent, Kyheng, Maeva, Duhamel, Alain, Pérez, Thierry, Pradat, Pierre François, Blasco, Hélène, Veyrat-Durebex, Charlotte, Corcia, Philippe, Oeckl, Patrick, Otto, Markus, Dupuis, Luc, Garçon, Guillaume, Defebvre, Luc, Cabantchik, Z. Ioav, Duce, James, Bordet, Régis, Devos, David
Formato: Artigo
Lenguaje:Inglês
Publicado: Mary Ann Liebert, Inc. 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6067092/
https://ncbi.nlm.nih.gov/pubmed/29287521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2017.7493
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