A thiol-reactive Ru(II) ion, not CO release, underlies the potent antimicrobial and cytotoxic properties of CO-releasing molecule-3

Carbon monoxide (CO)-releasing molecules (CORMs), mostly metal carbonyl compounds, are extensively used as experimental tools to deliver CO, a biological ‘gasotransmitter’, in mammalian systems. CORMs are also explored as potential novel antimicrobial drugs, effectively and rapidly killing bacteria...

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Udgivet i:Redox Biol
Main Authors: Southam, Hannah M., Smith, Thomas W., Lyon, Rhiannon L., Liao, Chunyan, Trevitt, Clare R., Middlemiss, Laurence A., Cox, Francesca L., Chapman, Jonathan A., El-Khamisy, Sherif F., Hippler, Michael, Williamson, Michael P., Henderson, Peter J.F., Poole, Robert K.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2018
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6067063/
https://ncbi.nlm.nih.gov/pubmed/30007887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2018.06.008
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