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Spontaneous CO Release from Ru(II)(CO)(2)–Protein Complexes in Aqueous Solution, Cells, and Mice**
We demonstrate that Ru(II)(CO)(2)–protein complexes, formed by the reaction of the hydrolytic decomposition products of [fac-RuCl(κ(2)-H(2)NCH(2)CO(2))(CO)(3)] (CORM-3) with histidine residues exposed on the surface of proteins, spontaneously release CO in aqueous solution, cells, and mice. CO relea...
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| Publicado no: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
WILEY-VCH Verlag
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4506567/ https://ncbi.nlm.nih.gov/pubmed/25477186 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201409344 |
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