‘Carbon-Monoxide-Releasing Molecule-2 (CORM-2)’ Is a Misnomer: Ruthenium Toxicity, Not CO Release, Accounts for Its Antimicrobial Effects

Carbon monoxide (CO)-releasing molecules (CORMs) are used to deliver CO, a biological ‘gasotransmitter’, in biological chemistry and biomedicine. CORMs kill bacteria in culture and in animal models, but are reportedly benign towards mammalian cells. CORM-2 (tricarbonyldichlororuthenium(II) dimer, Ru...

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Detalhes bibliográficos
Publicado no:Antioxidants (Basel)
Main Authors: Southam, Hannah M., Williamson, Michael P., Chapman, Jonathan A., Lyon, Rhiannon L., Trevitt, Clare R., Henderson, Peter J. F., Poole, Robert K.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8227206/
https://ncbi.nlm.nih.gov/pubmed/34198746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antiox10060915
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