The Impact of APP on Alzheimer-like Pathogenesis and Gene Expression in Down Syndrome iPSC-Derived Neurons

Early-onset Alzheimer disease (AD)-like pathology in Down syndrome is commonly attributed to an increased dosage of the amyloid precursor protein (APP) gene. To test this in an isogenic human model, we deleted the supernumerary copy of the APP gene in trisomic Down syndrome induced pluripotent stem...

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Udgivet i:Stem Cell Reports
Main Authors: Ovchinnikov, Dmitry A., Korn, Othmar, Virshup, Isaac, Wells, Christine A., Wolvetang, Ernst J.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2018
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6066957/
https://ncbi.nlm.nih.gov/pubmed/29861166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.05.004
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