Defective Transcytosis of APP and Lipoproteins in human iPSC-derived neurons with Familial Alzheimer’s Disease Mutations

We investigated early phenotypes caused by familial Alzheimer’s Disease (fAD) mutations in isogenic human iPSC-derived neurons. Analysis of neurons carrying fAD PS1 or APP mutations introduced using genome editing technology at the endogenous loci revealed that fAD mutant neurons had previously unre...

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Publicat a:Cell Rep
Autors principals: Woodruff, Grace, Reyna, Sol M., Dunlap, Mariah, Van Der Kant, Rik, Callender, Julia A., Young, Jessica E., Roberts, Elizabeth A., Goldstein, Lawrence S. B.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5796664/
https://ncbi.nlm.nih.gov/pubmed/27732852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.09.034
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