11 Beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis

OBJECTIVE: In rheumatoid arthritis, the enzyme 11 beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is highly expressed at sites of inflammation, where it converts inactive glucocorticoids (GC) to their active counterparts. In conditions of GC excess it has been shown to be a critical regulator of...

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Pubblicato in:J Autoimmun
Autori principali: Hardy, R.S., Fenton, C., Croft, A.P., Naylor, A.J., Begum, R., Desanti, G., Buckley, C.D., Lavery, G., Cooper, M.S., Raza, K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Academic Press 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6066611/
https://ncbi.nlm.nih.gov/pubmed/29891135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2018.05.010
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