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No off-target mutations in functional genome regions of a CRISPR/Cas9-generated monkey model of muscular dystrophy
CRISPR/Cas9 is now widely used in biomedical research and has great potential for clinical applications. However, the safety and efficacy of this gene-editing technique are significant issues. Recent reports on mouse models and human cells have raised concerns that off-target mutations could hamper...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6066302/ https://ncbi.nlm.nih.gov/pubmed/29941452 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.AC118.004404 |
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