Epoxymicheliolide, a novelguaiane-type sesquiterpene lactone, inhibits NF-κB/COX-2 signaling pathways by targeting leucine 281 and leucine 25 in IKKβ in renal cell carcinoma

Parthenolide (PTL) is a sesquiterpene lactone compound obtained from Tanacetum parthenium (feverfew) and inhibits the activation of nuclear factor (NF)-κB. Epoxymicheliolide (EMCL) is a compound which is structurally related to PTL; however, EMCL is more stable under acidic and alkaline conditions....

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Detalhes bibliográficos
Publicado no:Int J Oncol
Main Authors: Zhu, Jiabin, Zhao, Jun, Yu, Zhenlong, Shrestha, Sandeep, Song, Jing, Liu, Wenwen, Lan, Wen, Xing, Jinshan, Liu, Shuang, Chen, Chen, Cao, Momo, Sun, Xiuzhen, Wang, Qi, Song, Xishuang
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6065450/
https://ncbi.nlm.nih.gov/pubmed/29956738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2018.4460
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