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Epoxymicheliolide, a novelguaiane-type sesquiterpene lactone, inhibits NF-κB/COX-2 signaling pathways by targeting leucine 281 and leucine 25 in IKKβ in renal cell carcinoma
Parthenolide (PTL) is a sesquiterpene lactone compound obtained from Tanacetum parthenium (feverfew) and inhibits the activation of nuclear factor (NF)-κB. Epoxymicheliolide (EMCL) is a compound which is structurally related to PTL; however, EMCL is more stable under acidic and alkaline conditions....
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| Udgivet i: | Int J Oncol |
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| Main Authors: | , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
D.A. Spandidos
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6065450/ https://ncbi.nlm.nih.gov/pubmed/29956738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2018.4460 |
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