Alantolactone, a natural sesquiterpene lactone, has potent antitumor activity against glioblastoma by targeting IKKβ kinase activity and interrupting NF-κB/COX-2-mediated signaling cascades

BACKGROUND: Glioblastoma multiforme (GBM) is one of the most refractory and palindromic central nervous system (CNS) neoplasms, and current treatments have poor effects in GBM patients. Hence, the identification of novel therapeutic targets and the development of effective treatment strategies are e...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Wang, Xun, Yu, Zhenlong, Wang, Chao, Cheng, Wei, Tian, Xiangge, Huo, Xiaokui, Wang, Yan, Sun, Chengpeng, Feng, Lei, Xing, Jinshan, Lan, Yulong, Sun, Dongdong, Hou, Qingjuan, Zhang, Baojing, Ma, Xiaochi, Zhang, Bo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5508758/
https://ncbi.nlm.nih.gov/pubmed/28701209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-017-0563-8
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