Structural insights into SorCS2–Nerve Growth Factor complex formation

Signaling of SorCS receptors by proneurotrophin ligands regulates neuronal plasticity, induces apoptosis and is associated with mental disorders. The detailed structure of SorCS2 and its extracellular specificity are unresolved. Here we report crystal structures of the SorCS2–NGF complex and unligan...

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Vydáno v:Nat Commun
Hlavní autoři: Leloup, Nadia, Chataigner, Lucas M. P., Janssen, Bert J. C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6065357/
https://ncbi.nlm.nih.gov/pubmed/30061605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05405-z
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