Structural mechanism of AadA, a dual-specificity aminoglycoside adenylyltransferase from Salmonella enterica

Streptomycin and spectinomycin are antibiotics that bind to the bacterial ribosome and perturb protein synthesis. The clinically most prevalent bacterial resistance mechanism is their chemical modification by aminoglycoside-modifying enzymes such as aminoglycoside nucleotidyltransferases (ANTs). Aad...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Stern, Ana Laura, Van der Verren, Sander Egbert, Kanchugal P, Sandesh, Näsvall, Joakim, Gutiérrez-de-Terán, Hugo, Selmer, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6065190/
https://ncbi.nlm.nih.gov/pubmed/29871922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003989
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