Structural mechanism of AadA, a dual-specificity aminoglycoside adenylyltransferase from Salmonella enterica

Streptomycin and spectinomycin are antibiotics that bind to the bacterial ribosome and perturb protein synthesis. The clinically most prevalent bacterial resistance mechanism is their chemical modification by aminoglycoside-modifying enzymes such as aminoglycoside nucleotidyltransferases (ANTs). Aad...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Stern, Ana Laura, Van der Verren, Sander Egbert, Kanchugal P, Sandesh, Näsvall, Joakim, Gutiérrez-de-Terán, Hugo, Selmer, Maria
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2018
Ämnen:
Protein Structure and Folding
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6065190/
https://ncbi.nlm.nih.gov/pubmed/29871922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003989
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