Structural mechanism of AadA, a dual-specificity aminoglycoside adenylyltransferase from Salmonella enterica

Streptomycin and spectinomycin are antibiotics that bind to the bacterial ribosome and perturb protein synthesis. The clinically most prevalent bacterial resistance mechanism is their chemical modification by aminoglycoside-modifying enzymes such as aminoglycoside nucleotidyltransferases (ANTs). Aad...

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Publicat a:J Biol Chem
Autors principals: Stern, Ana Laura, Van der Verren, Sander Egbert, Kanchugal P, Sandesh, Näsvall, Joakim, Gutiérrez-de-Terán, Hugo, Selmer, Maria
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2018
Matèries:
Protein Structure and Folding
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6065190/
https://ncbi.nlm.nih.gov/pubmed/29871922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003989
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