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Analysis of heat-induced protein aggregation in human mitochondria

Proteins in mammalian cells exhibit optimal stability at physiological temperatures, and even small temperature variations may cause unfolding and nonspecific aggregation. Because this process leads to a loss of function of the affected polypeptides and to cytotoxic stress, formation of protein aggr...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Wilkening, Anne, Rüb, Cornelia, Sylvester, Marc, Voos, Wolfgang
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6065183/
https://ncbi.nlm.nih.gov/pubmed/29895621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002122
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