Ageing and hypoxia cause protein aggregation in mitochondria

Aggregation of cytosolic proteins is a pathological finding in disease states, including ageing and neurodegenerative diseases. We have previously reported that hypoxia induces protein misfolding in Caenorhabditis elegans mitochondria, and electron micrographs suggested protein aggregates. Here, we...

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Publicat a:Cell Death Differ
Autors principals: Kaufman, Daniel M, Wu, Xia, Scott, Barbara A, Itani, Omar A, Van Gilst, Marc R, Bruce, James E, Michael Crowder, C
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596417/
https://ncbi.nlm.nih.gov/pubmed/28644434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.101
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