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Neuronal Loss of Drosophila NPC1a Causes Cholesterol Aggregation and Age-Progressive Neurodegeneration

The mistrafficking and consequent cytoplasmic accumulation of cholesterol and sphingolipids is linked to multiple neurodegenerative diseases. One class of disease, the sphingolipid storage diseases, includes Niemann-Pick disease type C (NPC), caused predominantly (95%) by mutation of the NPC1 gene....

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Bibliographische Detailangaben
Hauptverfasser: Phillips, Scott E., Woodruff, E. A., Liang, Ping, Patten, Meaghan, Broadie, Kendal
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2008
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306184/
https://ncbi.nlm.nih.gov/pubmed/18579730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5529-07.2008
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