Anti‐TIM‐1 Monoclonal Antibody (RMT1‐10) Attenuates Atherosclerosis By Expanding IgM‐producing B1a Cells

BACKGROUND: Peritoneal B1a cells attenuate atherosclerosis by secreting natural polyclonal immunoglobulin M (IgM). Regulatory B cells expressing T‐cell immunoglobulin mucin domain‐1 (TIM‐1) expanded through TIM‐1 ligation by anti‐TIM‐1 monoclonal antibody (RMT1‐10) induces immune tolerance. METHODS...

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Bibliografiske detaljer
Udgivet i:J Am Heart Assoc
Main Authors: Hosseini, Hamid, Yi, Li, Kanellakis, Peter, Cao, Anh, Tay, Christopher, Peter, Karlheinz, Bobik, Alex, Toh, Ban‐Hock, Kyaw, Tin
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6064881/
https://ncbi.nlm.nih.gov/pubmed/29936416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.117.008447
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