Toxicity, recovery, and resilience in a 3D dopaminergic neuronal in vitro model exposed to rotenone

To date, most in vitro toxicity testing has focused on acute effects of compounds at high concentrations. This testing strategy does not reflect real-life exposures, which might contribute to long-term disease outcome. We used a 3D-human dopaminergic in vitro LUHMES cell line model to determine whet...

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Detalhes bibliográficos
Publicado no:Arch Toxicol
Main Authors: Harris, Georgina, Eschment, Melanie, Orozco, Sebastian Perez, McCaffery, J. Michael, Maclennan, Richard, Severin, Daniel, Leist, Marcel, Kleensang, Andre, Pamies, David, Maertens, Alexandra, Hogberg, Helena T., Freeman, Dana, Kirkwood, Alfredo, Hartung, Thomas, Smirnova, Lena
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2018
Assuntos:
In Vitro Systems
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6063347/
https://ncbi.nlm.nih.gov/pubmed/29955902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-018-2250-8
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