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Design and functional characterization of synthetic E3 ubiquitin ligases for targeted protein depletion: Selective protein knockout using engineered ubiquibodies
A number of techniques now exist for decreasing the expression of cellular proteins without the need for genomic modification. One such technique involves engineered protein chimeras that combine the ubiquitination activity of E3 ubiquitin ligases with the binding affinity and substrate specificity...
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| Udgivet i: | Curr Protoc Chem Biol |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6062852/ https://ncbi.nlm.nih.gov/pubmed/30040244 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpch.37 |
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