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Context-dependent AMPK activation distinctly regulates TAp73 stability and transcriptional activity
TAp73, the homologue of the tumour suppressor p53, has dual roles in tumourigenesis: both as a tumour suppressor and as a promoter of tumour growth. We have recently shown that hypoxia, a condition prevalent in tumours, results in the stabilisation of TAp73 through a mechanism involving HIF-1α-media...
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| Publicado no: | Signal Transduct Target Ther |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6062496/ https://ncbi.nlm.nih.gov/pubmed/30057793 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-018-0020-y |
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