A 7-methoxytacrine–4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication

Chemical warfare agents constitute an increasing threat to both military and civilian populations. Therefore, effective prophylactic approaches are urgently needed. Herein, we present a novel hybrid compound which is able not only to keep acetylcholinesterase resistant to organophosphate (OP) inhibi...

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Detalhes bibliográficos
Publicado no:Toxicol Res (Camb)
Main Authors: Nepovimova, E., Korabecny, J., Dolezal, R., Nguyen, T. D., Jun, D., Soukup, O., Pasdiorova, M., Jost, P., Muckova, L., Malinak, D., Gorecki, L., Musilek, K., Kuca, Kamil
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2016
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6062411/
https://ncbi.nlm.nih.gov/pubmed/30090408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6tx00130k
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