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Immune-evasive gene switch enables regulated delivery of chondroitinase after spinal cord injury

Chondroitinase ABC is a promising preclinical therapy that promotes functional neuroplasticity after CNS injury by degrading extracellular matrix inhibitors. Efficient delivery of chondroitinase ABC to the injured mammalian spinal cord can be achieved by viral vector transgene delivery. This approac...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Brain
Hauptverfasser: Burnside, Emily R, De Winter, Fred, Didangelos, Athanasios, James, Nicholas D, Andreica, Elena-Cristina, Layard-Horsfall, Hugo, Muir, Elizabeth M, Verhaagen, Joost, Bradbury, Elizabeth J
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6061881/
https://ncbi.nlm.nih.gov/pubmed/29912283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awy158
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