Hg(II) binds to C–T mismatches with high affinity

Binding reactions of Hg(II) and Ag(I) to pyrimidine-pyrimidine mismatches in duplex DNA were characterized using fluorescent nucleobase analogs, thermal denaturation and (1)H NMR. Unlike Ag(I), Hg(II) exhibited stoichiometric, site-specific binding of C–T mismatches. The on- and off-rates of Hg(II)...

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Udgivet i:Nucleic Acids Res
Main Authors: Schmidt, Olivia P, Benz, Andrea S, Mata, Guillaume, Luedtke, Nathan W
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
Fag:
Chemical Biology and Nucleic Acid Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6061796/
https://ncbi.nlm.nih.gov/pubmed/29901748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky499
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