Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice

Mitochondrial DNA (mtDNA) mutations become more prevalent with age and are postulated to contribute to the ageing process. Point mutations of mtDNA have been suggested to originate from two main sources, i.e. replicative errors and oxidative damage, but the contribution of each of these processes is...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Kauppila, Johanna H K, Bonekamp, Nina A, Mourier, Arnaud, Isokallio, Marita A, Just, Alexandra, Kauppila, Timo E S, Stewart, James B, Larsson, Nils-Göran
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6061787/
https://ncbi.nlm.nih.gov/pubmed/29860357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky456
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