Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice

Mitochondrial DNA (mtDNA) mutations become more prevalent with age and are postulated to contribute to the ageing process. Point mutations of mtDNA have been suggested to originate from two main sources, i.e. replicative errors and oxidative damage, but the contribution of each of these processes is...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Kauppila, Johanna H K, Bonekamp, Nina A, Mourier, Arnaud, Isokallio, Marita A, Just, Alexandra, Kauppila, Timo E S, Stewart, James B, Larsson, Nils-Göran
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
Assuntos:
Genome Integrity, Repair and Replication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6061787/
https://ncbi.nlm.nih.gov/pubmed/29860357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky456
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares