Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice

Mitochondrial DNA (mtDNA) mutations become more prevalent with age and are postulated to contribute to the ageing process. Point mutations of mtDNA have been suggested to originate from two main sources, i.e. replicative errors and oxidative damage, but the contribution of each of these processes is...

Full description

Saved in:
Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Kauppila, Johanna H K, Bonekamp, Nina A, Mourier, Arnaud, Isokallio, Marita A, Just, Alexandra, Kauppila, Timo E S, Stewart, James B, Larsson, Nils-Göran
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6061787/
https://ncbi.nlm.nih.gov/pubmed/29860357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky456
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items