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Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice
Mitochondrial DNA (mtDNA) mutations become more prevalent with age and are postulated to contribute to the ageing process. Point mutations of mtDNA have been suggested to originate from two main sources, i.e. replicative errors and oxidative damage, but the contribution of each of these processes is...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6061787/ https://ncbi.nlm.nih.gov/pubmed/29860357 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky456 |
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