A single-molecule sequencing assay for the comprehensive profiling of T4 DNA ligase fidelity and bias during DNA end-joining

DNA ligases are key enzymes in molecular and synthetic biology that catalyze the joining of breaks in duplex DNA and the end-joining of DNA fragments. Ligation fidelity (discrimination against the ligation of substrates containing mismatched base pairs) and bias (preferential ligation of particular...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Potapov, Vladimir, Ong, Jennifer L, Langhorst, Bradley W, Bilotti, Katharina, Cahoon, Dan, Canton, Barry, Knight, Thomas F, Evans, Thomas C, Lohman, Gregory J S
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Methods Online
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6061786/
https://ncbi.nlm.nih.gov/pubmed/29741723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky303
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