A single-molecule sequencing assay for the comprehensive profiling of T4 DNA ligase fidelity and bias during DNA end-joining

DNA ligases are key enzymes in molecular and synthetic biology that catalyze the joining of breaks in duplex DNA and the end-joining of DNA fragments. Ligation fidelity (discrimination against the ligation of substrates containing mismatched base pairs) and bias (preferential ligation of particular...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Nucleic Acids Res
Huvudupphovsmän: Potapov, Vladimir, Ong, Jennifer L, Langhorst, Bradley W, Bilotti, Katharina, Cahoon, Dan, Canton, Barry, Knight, Thomas F, Evans, Thomas C, Lohman, Gregory J S
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2018
Ämnen:
Methods Online
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6061786/
https://ncbi.nlm.nih.gov/pubmed/29741723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky303
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk