Metabolism and Toxicity of Trichloroethylene and Tetrachloroethylene in Cytochrome P450 2E1 Knockout and Humanized Transgenic Mice

Trichloroethylene (TCE) and tetrachloroethylene (PCE) are structurally similar olefins that can cause liver and kidney toxicity. Adverse effects of these chemicals are associated with metabolism to oxidative and glutathione conjugation moieties. It is thought that CYP2E1 is crucial to the oxidative...

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Опубликовано в: :Toxicol Sci
Главные авторы: Luo, Yu-Syuan, Furuya, Shinji, Soldatov, Valerie Y, Kosyk, Oksana, Yoo, Hong Sik, Fukushima, Hisataka, Lewis, Lauren, Iwata, Yasuhiro, Rusyn, Ivan
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2018
Предметы:
Toxicity of Tri- and Tetra-Chloroethylene Using Humanized Transgenic Mice
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6061689/
https://ncbi.nlm.nih.gov/pubmed/29897530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfy099
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