Metabolism and Toxicity of Trichloroethylene and Tetrachloroethylene in Cytochrome P450 2E1 Knockout and Humanized Transgenic Mice

Trichloroethylene (TCE) and tetrachloroethylene (PCE) are structurally similar olefins that can cause liver and kidney toxicity. Adverse effects of these chemicals are associated with metabolism to oxidative and glutathione conjugation moieties. It is thought that CYP2E1 is crucial to the oxidative...

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Dettagli Bibliografici
Pubblicato in:Toxicol Sci
Autori principali: Luo, Yu-Syuan, Furuya, Shinji, Soldatov, Valerie Y, Kosyk, Oksana, Yoo, Hong Sik, Fukushima, Hisataka, Lewis, Lauren, Iwata, Yasuhiro, Rusyn, Ivan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2018
Soggetti:
Toxicity of Tri- and Tetra-Chloroethylene Using Humanized Transgenic Mice
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6061689/
https://ncbi.nlm.nih.gov/pubmed/29897530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfy099
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