Metabolism and Toxicity of Trichloroethylene and Tetrachloroethylene in Cytochrome P450 2E1 Knockout and Humanized Transgenic Mice

Trichloroethylene (TCE) and tetrachloroethylene (PCE) are structurally similar olefins that can cause liver and kidney toxicity. Adverse effects of these chemicals are associated with metabolism to oxidative and glutathione conjugation moieties. It is thought that CYP2E1 is crucial to the oxidative...

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Gepubliceerd in:Toxicol Sci
Hoofdauteurs: Luo, Yu-Syuan, Furuya, Shinji, Soldatov, Valerie Y, Kosyk, Oksana, Yoo, Hong Sik, Fukushima, Hisataka, Lewis, Lauren, Iwata, Yasuhiro, Rusyn, Ivan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2018
Onderwerpen:
Toxicity of Tri- and Tetra-Chloroethylene Using Humanized Transgenic Mice
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6061689/
https://ncbi.nlm.nih.gov/pubmed/29897530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfy099
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