Metabolism and Toxicity of Trichloroethylene and Tetrachloroethylene in Cytochrome P450 2E1 Knockout and Humanized Transgenic Mice

Trichloroethylene (TCE) and tetrachloroethylene (PCE) are structurally similar olefins that can cause liver and kidney toxicity. Adverse effects of these chemicals are associated with metabolism to oxidative and glutathione conjugation moieties. It is thought that CYP2E1 is crucial to the oxidative...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Toxicol Sci
Prif Awduron: Luo, Yu-Syuan, Furuya, Shinji, Soldatov, Valerie Y, Kosyk, Oksana, Yoo, Hong Sik, Fukushima, Hisataka, Lewis, Lauren, Iwata, Yasuhiro, Rusyn, Ivan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2018
Pynciau:
Toxicity of Tri- and Tetra-Chloroethylene Using Humanized Transgenic Mice
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6061689/
https://ncbi.nlm.nih.gov/pubmed/29897530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfy099
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