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Mutagenicity of the Cysteine S-Conjugate Sulfoxides of Trichloroethylene and Tetrachloroethylene in the Ames Test

The nephrotoxicity and nephrocarcinogenicity of trichloroethylene (TCE) and tetrachloroethylene (PCE) are believed to be mediated primarily through the cysteine S-conjugate β-lyase-dependent bioactivation of the corresponding cysteine S-conjugate metabolites S-(1,2-dichlorovinyl)-L-cysteine (DCVC) a...

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Autori principali: Irving, Roy M., Elfarra, Adnan A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3631458/
https://ncbi.nlm.nih.gov/pubmed/23416178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2013.02.003
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