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Detection of Multiple Globin Monoadducts and Cross-Links after in Vitro Exposure of Rat Erythrocytes to S-(1,2-Dichlorovinyl)-L-cysteine Sulfoxide and after in Vivo Treatment of Rats with S-(1,2-Dichlorovinyl)-L-cysteine Sulfoxide

S-(1,2-Dichlorovinyl)-L-cysteine sulfoxide (DCVCS), a Michael acceptor produced by an FMO3-mediated oxidation of the trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine (DCVC), is a more potent nephrotoxicant than DCVC. Because DCVCS incubations with N-acetyl-L-cysteine at pH 7.4, 37°C res...

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Hlavní autoři: Barshteyn, Nella, Elfarra, Adnan A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575002/
https://ncbi.nlm.nih.gov/pubmed/18681461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx800060z
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