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Detection of Multiple Globin Monoadducts and Cross-Links after in Vitro Exposure of Rat Erythrocytes to S-(1,2-Dichlorovinyl)-L-cysteine Sulfoxide and after in Vivo Treatment of Rats with S-(1,2-Dichlorovinyl)-L-cysteine Sulfoxide
S-(1,2-Dichlorovinyl)-L-cysteine sulfoxide (DCVCS), a Michael acceptor produced by an FMO3-mediated oxidation of the trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine (DCVC), is a more potent nephrotoxicant than DCVC. Because DCVCS incubations with N-acetyl-L-cysteine at pH 7.4, 37°C res...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2575002/ https://ncbi.nlm.nih.gov/pubmed/18681461 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx800060z |
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