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Mass Spectral Analyses of Hydroxymethylvinyl Ketone-Hemoglobin Adducts Formed after in Vivo Exposure of Sprague-Dawley Rats to 3-Butene-1,2-Diol
3-Butene-1,2-diol (BDD), a known in vivo metabolite of 1,3-butadiene, is oxidized to a reactive Michael acceptor, hydroxymethylvinyl ketone (HMVK). Previously, we characterized formation of three HMVK-amino acid monoadducts when HMVK was incubated in vitro with N-acetyl-L-cysteine (NAC), L-valinamid...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2696584/ https://ncbi.nlm.nih.gov/pubmed/19419228 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx900079q |
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