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Mass Spectral Analyses of Hydroxymethylvinyl Ketone-Hemoglobin Adducts Formed after in Vivo Exposure of Sprague-Dawley Rats to 3-Butene-1,2-Diol

3-Butene-1,2-diol (BDD), a known in vivo metabolite of 1,3-butadiene, is oxidized to a reactive Michael acceptor, hydroxymethylvinyl ketone (HMVK). Previously, we characterized formation of three HMVK-amino acid monoadducts when HMVK was incubated in vitro with N-acetyl-L-cysteine (NAC), L-valinamid...

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Detalhes bibliográficos
Main Authors: Barshteyn, Nella, Elfarra, Adnan A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2696584/
https://ncbi.nlm.nih.gov/pubmed/19419228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx900079q
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