Dual tracer tau PET imaging reveals different molecular targets for (11)C-THK5351 and (11)C-PBB3 in the Alzheimer brain

PURPOSE: Several tau PET tracers have been developed, but it remains unclear whether they bind to the same molecular target on the heterogeneous tau pathology. In this study we evaluated the binding of two chemically different tau-specific PET tracers ((11)C-THK5351 and (11)C-PBB3) in a head-to-head...

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Detalhes bibliográficos
Publicado no:Eur J Nucl Med Mol Imaging
Main Authors: Chiotis, Konstantinos, Stenkrona, Per, Almkvist, Ove, Stepanov, Vladimir, Ferreira, Daniel, Arakawa, Ryosuke, Takano, Akihiro, Westman, Eric, Varrone, Andrea, Okamura, Nobuyuki, Shimada, Hitoshi, Higuchi, Makoto, Halldin, Christer, Nordberg, Agneta
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2018
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6061462/
https://ncbi.nlm.nih.gov/pubmed/29752516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00259-018-4012-5
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