The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication

Poly(ADP-ribose) is synthesized by PARP enzymes during the repair of stochastic DNA breaks. Surprisingly, however, we show that most if not all endogenous poly(ADP-ribose) is detected in normal S phase cells at sites of DNA replication. This S phase poly(ADP-ribose) does not result from damaged or m...

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Vydáno v:Mol Cell
Hlavní autoři: Hanzlikova, Hana, Kalasova, Ilona, Demin, Annie A., Pennicott, Lewis E., Cihlarova, Zuzana, Caldecott, Keith W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6060609/
https://ncbi.nlm.nih.gov/pubmed/29983321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.06.004
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