Intradermal immunization by Ebola virus GP subunit vaccines using microneedle patches protects mice against lethal EBOV challenge

Development of a safe and efficacious filovirus vaccine is of high importance to public health. In this study, we compared immune responses induced by Ebola virus (EBOV) glycoprotein (GP) subunit vaccines via intradermal immunization with microneedle (MN) patches and the conventional intramuscular (...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Liu, Ying, Ye, Ling, Lin, Fang, Gomaa, Yasmine, Flyer, David, Carrion, Ricardo, Patterson, Jean L., Prausnitz, Mark R., Smith, Gale, Glenn, Gregory, Wu, Hua, Compans, Richard W., Yang, Chinglai
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6060117/
https://ncbi.nlm.nih.gov/pubmed/30046140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-29135-w
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