Diabetes Exacerbates Myocardial Ischemia/Reperfusion Injury by Down-Regulation of MicroRNA and Up-Regulation of O-GlcNAcylation

Management for patients with diabetes experiencing myocardial infarction remains a challenge. Here the authors show that hyperglycemia- and hyperinsulinemia-induced microRNA-24 (miR-24) reduction and O-GlcNAcylation in the diabetic heart contribute to poor survival and increased infarct size in diab...

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Detalhes bibliográficos
Publicado no:JACC Basic Transl Sci
Main Authors: Wang, Dandan, Hu, Xiaoyue, Lee, Seung Hee, Chen, Feng, Jiang, Kai, Tu, Zizhuo, Liu, Zejian, Du, Jing, Wang, Li, Yin, Chaoying, Liao, Yu, Shang, Hongcai, Martin, Kathleen A., Herzog, Raimund I., Young, Lawrence H., Qian, Li, Hwa, John, Xiang, Yaozu
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
PRECLINICAL RESEARCH
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6058960/
https://ncbi.nlm.nih.gov/pubmed/30062222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2018.01.005
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